
OncoHost
Overview: OncoHost
At the core of OncoHost’s offerings is PROphetNSCLC™, the first liquid biopsy proteomics test designed to guide immunotherapy treatment choices in late-stage non-small cell lung cancer. Commercially available across the US, PROphetNSCLC™ provides clinicians with actionable insights based on one pre-treatment blood sample, allowing for personalized and effective therapeutic strategies.
While initially validated in NSCLC, PROphet® has shown promise in predicting clinical benefit in melanoma, renal cell carcinoma, HPV-associated malignancies, triple-negative breast cancer, small cell lung cancer, and colorectal cancer, suggesting the potential for multiple cancer applications.
OncoHost's dedication to rigorous scientific validation is evident in its multinational, multicenter clinical trial, spanning over 40 sites globally and has enrolled more than 1,700 patients, making it one of the largest studies in the field. The company is also at the forefront of biomarker innovation, with PROphet® being included in prestigious Phase III trials as a preferred exploratory biomarker for translational research.
With a world-class team of physicists, biologists, and clinicians, and a scientific advisory board comprising top industry leaders, OncoHost is setting new standards in biomarker-driven, patient-centered cancer care.
The details here are based on information received from, and verified solely by, the company.
Co Investors
OncoHost Management Team
Dr. Ofer Sharon
CEO
Dr. Ofer Sharon is a physician and entrepreneur with close to 20 years of experience in clinical and commercial product development for startups in the health tech, biotech, and medical device industries. Prior to joining Oncohost, he served multiple roles in global pharmaceutical companies including Medical Director for AstraZeneca (Israel), new technologies scout for Medimmune and Medical Director for MSD (Israel). He co-founded several healthcare companies, mainly focusing on bioinformatic and machine learning platforms for clinical deterioration detection and early intervention. Dr. Sharon is a Major (res.) in the IDF and a medical company commander with specific expertise in disaster relief. He received his MD cum laude from Tel Aviv University, Israel.
Steven Gottlieb, MD
Chairman
Steven M. Gottlieb, M.D. is a physician executive and healthcare serial entrepreneur with over 30 years of experience in the healthcare industry. He completed his specialty training in anesthesiology, pain management, and critical care medicine at The Johns Hopkins Hospital. He has founded, managed, funded, grown and exited several successful healthcare companies. Dr. Gottlieb has served on numerous boards of directors and in various leadership positions within hospital, community, corporate and professional organizations. His board positions (chairman, member or advisory) have included Medical Center Boards of Trustees, County Board of Health, EGPG, Anthem Associates, Anesthetix Holdings, Billing Management, Coagulo Medical Technologies, TruVue Analytics, Katao.
Prof. Yuval Shaked
Co-Founder & Chief Scientific Advisor
Prof. Yuval Shaked leads an academic research laboratory at the Rappaport Faculty of Medicine of the Technion – Israel Institute of Technology. His pioneering research, which focuses on understanding tumor-host interactions and therapy-induced mechanisms of tumor progression, serves as the scientific basis for Oncohost’s technology. Prof. Shaked is currently head of the Technion Integrated Cancer Center and President of the International Cancer Microenvironment Society. Formerly, he served as Vice Dean for Research at the Rappaport Faculty of Medicine of the Technion. In addition, he is a member of several cancer societies, including American Association for Cancer Research (AACR), European Association of Cancer Research (EACR) and Israel Society of Cancer Research (ISCR). Prof. Shaked is author and co-author of over 100 peer-reviewed publications and 5 patents, and a recipient of multiple competitive research grants including the prestigious European Research Council (ERC) grants. For his achievements, he has received numerous awards including the Igal Alon fellowship award for starting junior faculty, the Krill Prize for Excellence in Scientific Research, and the Youdim Family Prize for Excellence in Cancer Research. He received his PhD in biochemistry from the Hebrew University of Jerusalem, Israel, and completed his post-doctoral training at Sunnybrook Health Sciences Centre, University of Toronto, Canada.
Prof. Adam Dicker
Chief Medical Officer
Prof. Adam Dicker is a leading radiation oncologist, serving as Senior Vice President and Chair of Enterprise Radiation Oncology, Director of the Jefferson Institute for Digital Health, and Professor of Radiation Oncology and Pharmacology and Experimental Therapeutics at the Sidney Kimmel Cancer Center – Jefferson Health (SKCC). For his significant contributions to oncology research, education and patient care, Prof. Dicker has been named Fellow of the American Society of Clinical Oncology (FASCO) and Fellow of the American Society for Radiation Oncology (FASTRO). Among his numerous leadership positions are: Chair of the AACR’s Radiation Oncology Section of the Clinical Research Subcommittee; Chair of the ASCO-ASTRO Radiation Oncology Panel; Co-chair of NRG Oncology’s Translational Science and Digital Health committees; Co-Chair of the NCI Radiation Oncology Working Group; Editorial board member for several peer-reviewed journals.
Shani Raveh Shoval, PHD
VP Clinical Affairs
Dr. Shani Raveh Shoval has 15 years of experience in biological research and intellectual property. Prior to joining OncoHost, she was a project manager at Pluristem Therapeutics and intellectual property manager at Enzymotec. Dr. Shoval holds a PhD in molecular and cellular biology from the Weizmann Institute of Science.
Yehonatan Elon, PHD
CTO
Yehonatan Elon, PHD Dr. Yehonatan Elon has over 10 years of experience in the data and algorithms industry, with a proven track record in end-to-end product development. Dr. Elon holds a PhD in physics from the Weizmann Institute of Science, was director of new technologies at BrightSource Energy and VP of research at MeteoLogic and Feedvisor.
Michal Harel, PHD
Director of Science and Innovation
Dr. Michal Harel has over 8 years of experience in OMIC-level bioinformatic analysis, with strong expertise in working with proteomics data. Prior to joining OncoHost, Dr. Harel worked as a research associate at Tel Aviv University. She received her PhD from the Weizmann Institute of Science, followed by a post-doctoral period at the Technion – Israel Institute of Technology.
Itamar Sela, PHD
VP R&D
Dr. Itamar Sela is a multidisciplinary scientist specializing in mathematical modeling and data analysis, with extensive experience in physics and computational biology. Prior to joining OncoHost he was a postdoctoral fellow at the National Institutes of Health in Maryland USA, where he developed a theoretical framework to study quantitatively bacterial genome evolution. Dr. Sela received his PhD in theoretical physics from the Ben-Gurion University, followed by R&D positions in the industry and post-doctoral trainings.
Moti Hacham, LLB
CFO
Moti Hacham has over 20 years of versatile senior management, operational, financial and legal experience in the biotech industry, including positions at Spero Bio (CEO), Avraham Pharma (CFO&COO), Polyheal (COO), CureTech (CFO) and Clal Life Sciences (CEO). Previously an attorney at a leading law firm, and assistant to the CFO of Check Point Software Technologies (NASDAQ: CHKP). Moti holds a BA in Economics from the Tel-Aviv University, and an LLB from the Bar-Ilan University. He is a member of the Israeli Bar Association.
At a Glance: OncoHost
OncoHost is a technology company transforming the approach to precision medicine for improved patient outcomes. The company aims to understand the patient's unique response to therapy to overcome one of the major obstacles in clinical oncology today – resistance to treatment.
Supported by robust clinical evidence, strong IP positioning, and first-mover advantage, OncoHost developed the PROphet® platform. Combining bioinformatics, systems biology, proteomic pattern recognition, and AI, PROphet® provides clinicians with actionable clinical insights, optimal choice of therapy, and a better understanding of a patient’s personalized cancer dynamics.
Industry Challenge
Identifying patients who will benefit from immunotherapy is still a major challenge in clinical oncology. Most patients do not respond to these anti-cancer treatments, and some even display progression of disease while on treatment. The average response rate is in the range of 20% ‒ approximately one in five patients respond positively to the treatment.
To avoid unnecessary treatment, delays in administration, adverse reactions and/or unnecessary costs, it is important to identify, in advance, patients who will respond to their proposed treatment plan. For some treatments, biomarkers can help predict whether the patient will respond or not. But strong biomarkers are lacking for many cancer therapies, specifically for immunotherapy.
Disruptive Technology
PROphet® is disrupting the industry by providing the solutions to these unmet clinical needs. It answers the following physician’s questions:
- What is the optimal first-line therapy for my patient?
- Who will respond to single-agent immunotherapy vs. immunotherapy plus chemotherapy vs. chemotherapy alone?
- Is my patient a good candidate for a clinical trial? If so, which trial is best for my patient?
The first test indication, PROphetNSCLC™, optimizes first-line immunotherapy treatment outcomes for advanced, unresectable non-small cell lung cancer patients, predicting clinical benefit probability (at least 12 months of progression-free survival) in response to PD-1/PD-L1 inhibitors ‒ as a single agent or in combination with chemotherapy. PROphetNSCLC™ provides clinicians with actionable clinical insights into optimal first-line therapeutic choices, and a better understanding of their patient's personalized cancer dynamics.
PROphet® Development
The PROphet® algorithm is trained and validated on OncoHost’s large-scale clinical trial, PROPHETIC (NCT04056247). To date, the trial has over 1,700 patients recruited across 40 sites worldwide, making it one of the largest prospective cohorts in the precision oncology field. Indication-agnostic in nature, the PROphet® platform allows for multiple test indications, with its initial offering for late-stage non-small cell lung cancer (NSCLC) patients.
Information sourced from https://oncohost.com/, verified solely by the company.